867062-95-1

Usage

Uses

Used in Pharmaceutical Industry:
FMOC-12-AMINO-4,7,10-TRIOXADODECANOIC ACID is used as a building block for the synthesis of pharmaceuticals and bioconjugates. Its Fmoc-protected amine allows for selective deprotection and conjugation to other molecules, while the terminal carboxylic acid can form stable amide bonds with primary amines.
Used in Vaccine Development:
FMOC-12-AMINO-4,7,10-TRIOXADODECANOIC ACID is used as a reactant in the preparation of vaccines. Its ability to form stable amide bonds with primary amines makes it a valuable component in the synthesis of vaccine candidates.
Used in Bioconjugation:
FMOC-12-AMINO-4,7,10-TRIOXADODECANOIC ACID is used as a linker in bioconjugation, allowing for the attachment of various molecules to create new functional materials. Its Fmoc-protected amine and terminal carboxylic acid enable selective conjugation and stable bond formation.

InChI:InChI=1/C24H29NO7/c25-22(16-31-14-13-30-12-11-29-10-9-23(26)27)24(28)32-15-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-8,21-22H,9-16,25H2,(H,26,27)

Upstream product

• 139115-92-7 tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamate 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 252881-74-6 tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate 
• 1024602-74-1 tert-butyl 3-(2-{2-[2-(methanesulphonyloxy)ethoxy]ethoxy}ethoxy)propanoate 
• 252881-73-5 tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 186020-66-6 3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester 

Relevant academic research and scientific papers

Polypeptide, protein PEG modifier synthesis method

The present invention discloses a synthesis route and an operation method of a peptide and protein pegylation agent, wherein the pegylation agent is used for polypeptides and drug structure modification, the raw materials of the method are cheap, and the amount of the polyethylene glycol can be defined.

Synthesis of tumor-associated MUC1-glycopeptides and their multivalent presentation by functionalized gold colloids

The mucin MUC1 is a glycoprotein involved in fundamental biological processes, which can be found over-expressed and with a distinctly altered glycan pattern on epithelial tumor cells; thus it is a promising target structure in the quest for effective carbohydrate-based cancer vaccines and immunotherapeutics. Natural glycopeptide antigens indicate only a low immunogenicity and a T-cell independent immune response; however, this major drawback can be overcome by coupling of glycopeptide antigens multivalently to immunostimulating carrier platforms. In particular, gold nanoparticles are well suited as templates for the multivalent presentation of glycopeptide antigens, due to their remarkably high surface-to-volume ratio in combination with their high biostability. In this work the synthesis of novel MUC1-glycopeptide antigens and their coupling to gold nanoparticles of different sizes are presented. In addition, the development of a new dot-blot immunoassay to test the potential antigen-antibody binding is introduced.