867150-38-7Relevant academic research and scientific papers
Enzymes responsible for the conversion of Nα-[(benzyloxy) carbonyl]-D-lysine to Nα-[(benzyloxy)carbonyl]-D-aminoadipic acid by Rhodococcus sp. AIU Z-35-1
Isobe, Kimiyasu,Fukuda, Nahoko,Nagasawa, Shouko,Saitou, Kaoru
, p. 1549 - 1554 (2010)
The enzymes responsible for the conversion of Nα- [(benzyloxy)carbonyl]-D-lysine (Nα-Z-D-lysine) to N α-Z-D-aminoadipic acid (Nα-Z-D-AAA) by Rhodococcus sp. AIU Z-35-1 were identified. Nα-Z-D-Lysine was first converted to Nα-Z-D-aminoadipic δ-semialdehyde (Nα-Z-D-AASA) by D-specific amino acid deaminase, whereas Nα-Z-L-lysine was converted to Nα-Z-L-AASA by L-specific amino acid oxidase. The resulting Nα-Z-D-AASA was then converted to Nα-Z-D-AAA by the same aldehyde dehydrogenase that is responsible for Nα-Z-L-AASA oxidation. The product amount of the D-specific amino acid deaminase reached the maximum at one day of cultivation in the L-lysine medium. The aldehyde dehydrogenase reached the maximum at three days of cultivation.
