24325-15-3

Basic information

• Product Name: Hexanedioic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, (2R)-
• CAS NO: 24325-15-3
• Molecular Formula: C14H17NO6
• Molecular Weight: 295.292
• Mol File: 24325-15-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Hexanedioic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Hexanedioic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, (2R)-(24325-15-3)
• EPA Substance Registry System: Hexanedioic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, (2R)-(24325-15-3)

Safety Data

• Hazardous Substances Data: 24325-15-3(Hazardous Substances Data)

Upstream product

• 7620-28-2 D-2-aminoadipic acid 
• 501-53-1 benzyl chloroformate 
• 24325-12-0 (+/-)-2-chloroacetaminohexanedioic acid 
• 71301-34-3 (R)-2-chloroacetaminohexanedioic acid 
• 867150-38-7 Nα-Z-D-aminoadipic acid-δ-semialdehyde 

Downstream Products

• 135841-18-8 D-4-(3-benzyloxycarbonyl-5-oxo-4-oxazolidinyl)butanoic acid 
• 1353042-31-5 (R)-benzyl 2-benzyloxycarbonyl-1,2,3,4-tetrahydropyridine-2-carboxylate 
• 1353042-29-1 (R)-benzyl 1-benzyloxycarbonyl-5-formyl-1,2,3,4-tetrahydropyridine-2-carboxylate 
• 1353042-30-4 N-benzyloxycarbonyl-(R)-pipecolic acid benzyl ester 
• 24325-16-4 N-benzyloxycarbonyl-(R)-α-aminoadipic acid α-benzyl ester 
• 132974-96-0 benzyl-6-<4-(3-benzyloxycarbonyl-5-oxo-4-oxazolidinyl)butyrylamino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate 
• 103548-48-7 (R)-benzyl 2-benzyloxycarbonylamino-9-(4-imidazolyl)-7-azanonanoate 
• 103548-45-4 (R)-2-(benzyloxycarbonylamino)-6-hydroxyhexanoic benzyl ester 
• 103548-46-5 (R)-benzyl 6-oxo-2-benzyloxycarbonylaminohexanoate 

Relevant articles and documents

(R)-α-aminoadipic acid: An interesting chiral pool building block

(R)-α-Aminoadipic acid is available on a large scale by enzymatic cleavage from cephalosporin C (CephC) in the production of 7- aminocephalosporanic acid (7-ACA). It can be converted into other interesting enantiomerically pure compounds, e.g. derivatives of (R)-pipecolic acid (Rpiperidine 2-carboxylic acid), (R)-6-oxopiperidine-2-carboxylic acid, (R)-1,2,3,4-tetrahydropyridine 2(2H)-carboxylates, and other compounds obtained by further conversions of these products. ARKAT-USA, Inc.

THIAZOLIDINE DERIVATIVES

An object of the present invention is to provide novel thiazolidine derivatives which are useful as drugs. The thiazolidine derivatives according to the present invention are compounds represented by the following general formula [I] and salts thereof, wherein R 1is alkyl, hydroxy, alkoxy, alkoxyalkyl, phenyl, phenylalkyl, phenylalkoxy, phenoxy, phenoxyalkyl, amino, alkylamino or a nonaromatic heterocycle; R 2is H or alkyl; R 3is H, alkyl or phenyl; R 4is H or alkyl; R 5is alkyl, halogenoalkyl, hydroxy, alkoxy, phenyl, phenylalkoxy, phenoxy, carboxyl, alkoxycarbonyl, phenylalkoxycarbonyl or an aromatic heterocycle; A 1is alkylene; and A 2is alkylene.

SYNTHESIS OF THE RACEMIC AND OPTICALLY ACTIVE FORMS OF GIZZEROSINE, THE INDUCER OF GIZZARD EROSION IN CHICKS

The racemate end both the (R)- and (S)-forms of gizzerosine were synthesised, and the (S)-isomer was identified as the toxic substance in fish meal causing severe gizzard erosion (black vomit) in chicks.