86718-16-3 Usage
Uses
Used in Pharmaceutical Industry:
4-(AcetylaMino)-2-ethoxy-5-nitrobenzoic Acid Methyl Ester is used as a reactant for the preparation of Cinitapride (C441990), a drug with gastroprokinetic and antiemetic properties. It aids in the treatment of gastrointestinal disorders by enhancing gastric emptying and reducing nausea and vomiting.
Additionally, 4-(AcetylaMino)-2-ethoxy-5-nitrobenzoic Acid Methyl Ester is used as a reactant in the synthesis of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives. These derivatives possess antiemetic and gastroprokinetic activities, making them valuable in the development of medications for the treatment of gastrointestinal motility disorders and related symptoms.
Check Digit Verification of cas no
The CAS Registry Mumber 86718-16-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,7,1 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 86718-16:
(7*8)+(6*6)+(5*7)+(4*1)+(3*8)+(2*1)+(1*6)=163
163 % 10 = 3
So 86718-16-3 is a valid CAS Registry Number.
86718-16-3Relevant academic research and scientific papers
A novel series of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with dual antiemetic and gastroprokinetic activities
Hirokawa, Yoshimi,Yamazaki, Hiroshi,Yoshida, Naoyuki,Kato, Shiro
, p. 1973 - 1978 (2007/10/03)
A novel series of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with a medium perhydroazacycle ring in the amine moiety were prepared, and their antiemetic and gastroprokinetic activities were evaluated. Among them, N-(1-ethylhexahydroazepin-3-yl)-, N-(1-ethyloctahydroazocin-3-yl)- and N-(1- ethyloctahydroazonin-3-yl)-6-methoxy-1H-benzotriazole-5-carboxamides (24, 36, 37) showed a potent antiemetic activity (inhibition of apomorphine-induced emesis in dogs) along with gastroprokinetic activity (gastric emptying in rats).
Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
-
, (2008/06/13)
Novel N-(3-hydroxy-4-piperidinyl)benzamides and derivatives thereof, said compounds being useful as stimulators of the motility of the gastro-intestinal system.
