867219-48-5Relevant academic research and scientific papers
Asymmetric synthesis of photophore-containing lactisole derivatives to elucidate sweet taste receptors
Hashimoto, Makoto,Ishida, Akiko,Misaka, Takumi,Nakagita, Tomoya,Tachrim, Zetryana Puteri,Wang, Lei
, (2020)
Lactisole, which has a 2-phenoxy propionic acid skeleton, is well-known as an inhibitor of sweet taste receptors. We recently revealed some of the structure-activity relationships of the aromatic ring and chiral center of lactisole. Photoaffinity labeling
Binding of acetylcholine and quaternary ammonium compounds to a C 3-symmetric bowl-shaped tripeptide of 2-(3-aminophenoxy)propanoic acids acting as a ditopic receptor
Akazome, Motohiro,Hamada, Norihiro,Takagi, Koji,Yagyu, Daisuke,Matsumoto, Shoji
, p. 2226 - 2229 (2014/04/17)
The new tripeptide reported here is composed of (R)-2-(3-aminophenoxy) propionic acid and is a bowl-shaped receptor that simultaneously binds both cations and anions of acetylcholine chloride and benzyltrimethylammonium compounds. An intriguing conformati
PIPERIDINE DERIVATES FOR THE TREATMENT OF CHEMOKINES MEDIARED DISEASE
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Page/Page column 30, (2010/02/14)
The present invention provides a compound of a formula (I) wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.
