867279-67-2

Upstream product

• 867279-72-9 (1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (R)-(6-bromo-pyridin-2-yl)-phenyl-methyl ester 
• 80100-17-0 (6-bromopyridin-2-yl)(phenyl)methanone 
• 234111-09-2 6-bromo-α-phenyl-2-pyridinemethanol 

Downstream Products

• 1012043-19-4 (+)-(1S,2S)-1,2-bis(6-bromopyridin-2-yl)-1,2-diphenylethane 

Relevant academic research and scientific papers

Copper-catalyzed synthesis of enantioenriched tetraarylethanes

Herein we report the asymmetric synthesis of 1,2-dipyridyl-1,2- diarylethanes via an unusual Cu(l)-catalyzed dimerization reaction. Subjection of a variety of enantioenriched substituted 2-pyridyl alcohols to a one-pot protocol generates the desired products in good yields and diastereoselectivities and with ee's up to >99%.

New efficient method for the synthesis of chiral 2,2′-bipyridyl ligands

An efficient preparation of chiral 2,2′-bipyridines was developed. Compound 1 was synthesized in 54% yield for three steps starting from 2,6-dibromopyridine. In this synthesis, only catalytic amounts of metals were used in the asymmetric reduction and homo-coupling reaction steps. The total yield and simplicity of experimental procedures were much improved compared with those of the previous report. Other chiral 2,2′-bipyridines were similarly synthesized with high efficiency. Georg Thieme Verlag Stuttgart.