867279-72-9Relevant academic research and scientific papers
New efficient method for the synthesis of chiral 2,2′-bipyridyl ligands
Ishikawa, Shunpei,Hamada, Tomoaki,Manabe, Kei,Kobayashi, Shu
, p. 2176 - 2182 (2005)
An efficient preparation of chiral 2,2′-bipyridines was developed. Compound 1 was synthesized in 54% yield for three steps starting from 2,6-dibromopyridine. In this synthesis, only catalytic amounts of metals were used in the asymmetric reduction and homo-coupling reaction steps. The total yield and simplicity of experimental procedures were much improved compared with those of the previous report. Other chiral 2,2′-bipyridines were similarly synthesized with high efficiency. Georg Thieme Verlag Stuttgart.
