86732-18-5Relevant academic research and scientific papers
Amino-substituted tricyclic derivatives and methods of use
-
Page/Page column 61, (2010/02/14)
Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.
Synthesis and Carbon-13 NMR Study of 2-Benzyl, 2-Methyl, 2-Aryloctahydropyrrolopyrroles and the 1,2,3,5-Tetrahydropyrrolopyrrole Ring System
Ohnmacht, Cyrus J.,Draper, Clyde W.,Dedinas, Robert F.,Loftus, Philip,Wong, J. J.
, p. 321 - 329 (2007/10/02)
2-Benzyl, 2-phenyl, 2-(3-methoxyphenyl) and 2-(3-trifluoromethylphenyl)octahydropyrrolopyrrole (9a, 9b, 9c and 9d, respectively) were prepared in five steps from 1-benzylpyrrole-3,4-dicarboxylic acid (2). 2-Methyloctahydropyrrolopyrrole (9'a
