867331-09-7Relevant articles and documents
The design and preliminary structure-activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymes
Cao, Jianguo,Fine, Richard,Gritzen, Colleen,Hood, John,Kang, Xinshan,Klebansky, Boris,Lohse, Dan,Mak, Chi Ching,McPherson, Andrew,Noronha, Glenn,Palanki, Moorthy S.S.,Pathak, Ved P.,Renick, Joel,Soll, Richard,Zeng, Binqi,Zhu, Hong
, p. 5812 - 5818 (2008/03/14)
We describe the design, synthesis and structure-activity relationship studies in optimizing a series of benzotriazine compounds as potent inhibitors of both Abl and Abl-T315I enzymes. The design includes targeting of an acid functional residue on the αC-h
Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors
Noronha, Glenn,Barrett, Kathy,Cao, Jianguo,Dneprovskaia, Elena,Fine, Richard,Gong, Xianchang,Gritzen, Colleen,Hood, John,Kang, Xinshan,Klebansky, Boris,Li,Liao,Lohse, Dan,Mak, Chi Ching,McPherson, Andrew,Palanki, Moorthy S.S.,Pathak, Ved P.,Renick, Joel,Soll, Richard,Splittgerber, Ute,Wrasidlo, Wolfgang,Zeng, Binqi,Zhao, Ningning,Zhou
, p. 5546 - 5550 (2007/10/03)
We report the discovery and preliminary SAR studies of a series of structurally novel benzotriazine core based small molecules as inhibitors of Src kinase. To the best of our knowledge, benzotriazine template based compounds have not been reported as kina
Benzotriazine inhibitors of kinases
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Page/Page column 49, (2008/06/13)
The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
