867353-43-3 Usage
Uses
Used in Pharmaceutical Industry:
Pyrido[2,3-d]pyrimidine, 7-chloro-2-(methylthio)-6-phenylis used as a potential therapeutic agent for the development of new drugs. Its unique structure allows it to target specific biological pathways and receptors, making it a promising candidate for treating various diseases and conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, Pyrido[2,3-d]pyrimidine, 7-chloro-2-(methylthio)-6-phenylserves as a valuable compound for studying its interactions with biological targets. Researchers use Pyrido[2,3-d]pyrimidine, 7-chloro-2-(methylthio)-6-phenyl- to understand its binding affinity, selectivity, and potential effects on cellular processes, which can lead to the discovery of new drug candidates with improved efficacy and safety profiles.
Used in Drug Design and Optimization:
Pyrido[2,3-d]pyrimidine, 7-chloro-2-(methylthio)-6-phenylis utilized in the design and optimization of new drug molecules. Its structural features can be modified to enhance its pharmacological properties, such as potency, selectivity, and bioavailability. Pyrido[2,3-d]pyrimidine, 7-chloro-2-(methylthio)-6-phenylserves as a starting point for the development of novel therapeutic agents with improved therapeutic indices.
Used in Chemical Synthesis:
Pyrido[2,3-d]pyrimidine, 7-chloro-2-(methylthio)-6-phenylis also used as a key intermediate in the synthesis of other related compounds with potential biological activities. Its versatile structure allows for various chemical modifications, enabling the synthesis of a wide range of heterocyclic compounds with diverse pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 867353-43-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,7,3,5 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 867353-43:
(8*8)+(7*6)+(6*7)+(5*3)+(4*5)+(3*3)+(2*4)+(1*3)=203
203 % 10 = 3
So 867353-43-3 is a valid CAS Registry Number.
867353-43-3Relevant academic research and scientific papers
Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors
Wu, Zhicai,Hartnett, John C.,Neilson, Lou Anne,Robinson, Ronald G.,Fu, Sheng,Barnett, Stanley F.,Defeo-Jones, Deborah,Jones, Raymond E.,Kral, Astrid M.,Huber, Hans E.,Hartman, George D.,Bilodeau, Mark T.
, p. 1274 - 1279 (2008/09/19)
This communication reports a new synthetic route of pyridopyrimidines to facilitate their structural optimization in a library fashion and describes the development of pyridopyrimidines that have excellent enzymatic and cell potency against Akt1 and Akt2.
INHIBITORS OF AKT ACTIVITY
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Page/Page column 50-51, (2008/06/13)
The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
INHIBITORS OF AKT ACTIVITY
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Page/Page column 48, (2010/02/14)
The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
