867353-44-4

Basic information

• Product Name: Benzaldehyde, 4-[2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]-
• CAS NO: 867353-44-4
• Molecular Formula: C21H15N3OS
• Molecular Weight: 357.436
• Mol File: 867353-44-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-[2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-[2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]-(867353-44-4)
• EPA Substance Registry System: Benzaldehyde, 4-[2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]-(867353-44-4)

Safety Data

• Hazardous Substances Data: 867353-44-4(Hazardous Substances Data)

Upstream product

• 867353-43-3 7-chloro-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidine 
• 87199-17-5 4-formylphenylboronic acid, 

Downstream Products

• 867351-65-3 N-3-{4-[2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzyl}-beta-alaninamide 
• 882047-23-6 C₃₄H₃₁N₇S 
• 882047-21-4 C₃₃H₂₉N₇OS 
• 1019775-45-1 C₃₁H₂₇N₇S 
• 1019775-44-0 C₂₆H₂₅N₇S 
• 1019775-43-9 C₂₇H₂₆N₆S 
• 1019775-42-8 C₂₈H₂₅N₅S 
• 1019775-40-6 C₂₅H₂₃N₇S 
• 1019775-41-7 C₂₆H₂₃N₅S₂ 

Relevant articles and documents

Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors

This communication reports a new synthetic route of pyridopyrimidines to facilitate their structural optimization in a library fashion and describes the development of pyridopyrimidines that have excellent enzymatic and cell potency against Akt1 and Akt2.

INHIBITORS OF AKT ACTIVITY

The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.