867367-99-5

Upstream product

• 504-15-4 orcinol 
• 487-69-4 2,4-dihydroxy-6-methylbenzaldehyde 
• 3188-13-4 ethyl chloromethyl ether 

Downstream Products

• 867367-88-2 2,4-bis-ethoxymethoxy-6-methyl-benzoic acid 2-trimethylsilanyl-ethyl ester 
• 1007313-79-2 3-chloro-4,6-bis(ethoxymethoxy)-2-methylbenzoic acid 
• 1007313-92-9 2,4-bis-ethoxymethoxy-6-methyl-benzoic acid 

Relevant academic research and scientific papers

MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90

Disclosed are macrocyclic compounds of formulae I-V,which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90.

Solution- and solid-phase synthesis of radicicol (monorden) and pochonin C

A modular synthesis for pochonin C and radicicol is reported. The two natural products were prepared in seven and eight steps, respectively, from three readily available fragments. Alternative syntheses of these compounds were achieved using a combination of polymer-bound reagents and solid phase reactions. The conformation of the two natural products was studied and compared by using 2D NMR spectroscopy.