867371-79-7

Upstream product

• 854300-44-0 3-[4(S)-(Boc-amino)-1,2,4,5-tetrahydro-2-benzazepine-3-one-2-yl]-2(S)-Fmoc-amino-1-(2,6-dimethyl-4-hydroxyphenyl)propane 
• 854300-33-7 Fmoc-L-Dmt-N,O-Me₂ 
• 854300-35-9 Fmoc-L-Dmt(Moc)-N,O-Me₂ 
• 216312-53-7 N^α-[(tert-butoxy)carbonyl]-2-cyano-L-phenylalanine 
• 639478-81-2 (S)-3-(2-(aminomethyl)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid 

Downstream Products

• 854300-52-0 [1-(4-hydroxy-2,6-dimethylbenzyl)-2(S)-(3-oxo-4(S)-phenylacetylamino-1,2,4,5-tetrahydrobenzo[c]azepin-2-yl)-ethyl]carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant academic research and scientific papers

A new structural motif for μ-opioid antagonists

On the basis of the structural features of the Dmt-Tic pharmacophore, a new motif leading to a fairly potent μ-opioid antagonist is described. This motif contains the 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-one skeleton as a substitute for the Tic resi