86775-96-4Relevant academic research and scientific papers
AKT3 MODULATORS
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Paragraph 0421, (2021/11/13)
Compounds of Formula la, lb, or Ic,, are described, where the various substituents are defined herein. The compounds can modulate a property or effect of Akt3 in vitro or in vivo, and can also be used, individually or in combination with other agents, in the prevention or treatment of a variety of conditions. Methods for synthesizing the compounds are described. Pharmaceutical compositions and methods of using these compounds or compositions, individually or in combination with other agents or compositions, in the prevention or treatment of a variety of conditions are also described.
Selective Functionalization of Aminoheterocycles by a Pyrylium Salt
Moser, Daniel,Duan, Yaya,Wang, Feng,Ma, Yuanhong,O'Neill, Matthew J.,Cornella, Josep
, p. 11035 - 11039 (2018/07/31)
The functionalization of aminoheterocycles by using a pyrylium tetrafluoroborate reagent (Pyry-BF4) is presented. This reagent efficiently condenses with a great variety of heterocyclic amines and primes the C?N bond for nucleophilic aromatic substitution. More than 60 examples for the formation of C?O, C?N, C?S, or C?SO2R bonds are disclosed herein. In contrast to C?N activation through diazotization and polyalkylation, this method is characterized by its mild conditions and impressive functional-group tolerance. In addition to small-molecule derivatization, Pyry-BF4 allows the introduction of functional groups in a late-stage fashion to furnish highly functionalized structures.
Synthetic Applications of N-N Linked Heterocycles. Part 15. A Facile Synthesis of 4-Pyridyl(aryl)amines via the Reaction between 4-Chloro-1-pyridiniopyridinium Salts and Aryl Amines
Sammes, Michael P.,Ho, King-Wah,Tam, Ming-Lim,Katritzky, Alan R.
, p. 973 - 978 (2007/10/02)
4-Chloro-1-pyridiniopyridinium salts (7) and (8) react with primary and secondary arylamines to give high yields of isolable 4-aryliminium salts (9) and (10).These are readily fragmented into 4-pyridyl(aryl)amines (11) and (12) in excellent yields on treatment with sodium cyanide or sodium salts of sulphonic acids.The method fails with the more basic aliphatic amines, since these apparently attack the 2-position of the chloropyridinium ring giving products resulting from ring-opening.Mechanisms of the reactions are discussed.
