80028-43-9

Basic information

• Product Name: Benzoic acid, 4-(4-pyridinylamino)-
• CAS NO: 80028-43-9
• Molecular Formula: C12H10N2O2
• Molecular Weight: 214.224
• Mol File: 80028-43-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(4-pyridinylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(4-pyridinylamino)-(80028-43-9)
• EPA Substance Registry System: Benzoic acid, 4-(4-pyridinylamino)-(80028-43-9)

Safety Data

• Hazardous Substances Data: 80028-43-9(Hazardous Substances Data)

Upstream product

• 626-61-9 4-Chloropyridine 
• 150-13-0 4-amino-benzoic acid 
• 22752-98-3 N-(4-pyridyl)pyridinium hydrochloride 
• 86775-96-4 methyl 4-(pyridin-4-ylamino)benzoate 
• 619-45-4 4-methoxycarbonyl aniline 
• 504-24-5 4-aminopyridine 
• 1120-87-2 4-bromopyridin 

Downstream Products

• 32567-71-8 N-(4-nitrophenyl)-4-(4-pyridinylamino)benzamide 
• 1020087-04-0 4-{4-[(4-aminoanilino)carbonyl]anilino}-1-methylpyridinium chloride 
• 1020087-01-7 1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium chloride 
• 1422207-89-3 C₃₀H₃₂N₄O₂ 

Relevant articles and documents

AKT3 MODULATORS

Compounds of Formula la, lb, or Ic,, are described, where the various substituents are defined herein. The compounds can modulate a property or effect of Akt3 in vitro or in vivo, and can also be used, individually or in combination with other agents, in the prevention or treatment of a variety of conditions. Methods for synthesizing the compounds are described. Pharmaceutical compositions and methods of using these compounds or compositions, individually or in combination with other agents or compositions, in the prevention or treatment of a variety of conditions are also described.

QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION

Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.

Pyrimidine benzamide-based thrombopoietin receptor agonists

A series of pyrimidine benzamide-based thrombopoietin receptor agonists is described. The lead molecule contains a 2-amino-5-unsubstituted thiazole, a group that has been associated with idiosyncratic toxicity. The potential for metabolic oxidation at C-5 of the thiazole, the likely source of toxic metabolites, was removed by substitution at C-5 or by replacing the thiazole with a thiadiazole. Potency in the series was improved by modifying the substituents on the pyrimidine and/or on the thiazole or thiadiazole pendant aryl ring. In vivo examination revealed that compounds from the series are not highly bioavailable. This is attributed to low solubility and poor permeability.