86784-80-7

Basic information

• Product Name: CRF (HUMAN, RAT)
• Synonyms: SER-GLU-GLU-PRO-PRO-ILE-SER-LEU-ASP-LEU-THR-PHE-HIS-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-ALA-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-HIS-SER-ASN-ARG-LYS-LEU-MET-GLU-ILE-ILE-NH2;SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2;CORTICOTROPIN RELEASING FACTOR;CORTICOTROPIN RELEASING FACTOR (CRF), HUMAN, RAT;CORTICOTROPIN RELEASING FACTOR, HUMAN;CORTICOTROPIN RELEASING FACTOR, HUMAN AND RAT;CORTICOTROPIN RELEASING FACTOR HUMAN, RAT;CRF, HUMAN AND RAT
• CAS NO: 86784-80-7
• Molecular Formula: C208H344N60O63S2
• Molecular Weight: 4757.45
• Product Categories: Peptide;CRF receptor and related;proteins
• Mol File: 86784-80-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: CRF (HUMAN, RAT)(CAS DataBase Reference)
• NIST Chemistry Reference: CRF (HUMAN, RAT)(86784-80-7)
• EPA Substance Registry System: CRF (HUMAN, RAT)(86784-80-7)

Safety Data

• WGK Germany: 3
• RTECS: GM7925000
• F: 10
• Hazardous Substances Data: 86784-80-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 86784-80-7 differently. You can refer to the following data:
1. Treatment of symptoms associated with peritumoral edema in brain tumor patients.
2. Corticotropin Releasing Factor human, rat has been used:as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explantsas a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cellsin the synthesis of the corticotropin-releasing factor(CRF)-TAMRA?1?mixturein chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus

Brand name

Xerecept (Hollister-Stier) [Note—The source of the product (human, porcine, etc.) must be indicated in the labeling.].

General Description

Corticotropin-releasing factor is a 41-amino-acid polypeptide. It is expressed in neurons, hypothalamus?and amygdala.

Biochem/physiol Actions

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

InChI:InChI=1/C208H343N59O64S2/c1-30-106(20)161(263-198(323)147-49-41-75-266(147)204(329)148-50-42-76-267(148)203(328)132(59-68-158(286)287)246-179(304)126(55-64-154(278)279)235-169(294)117(210)93-268)200(325)260-146(95-270)197(322)253-137(83-102(12)13)189(314)256-144(90-159(288)289)194(319)252-139(85-104(16)17)195(320)265-164(113(27)271)202(327)258-140(86-114-43-34-33-35-44-114)190(315)254-142(88-116-92-222-97-227-116)191(316)251-136(82-101(10)11)188(313)250-135(81-100(8)9)185(310)237-121(48-40-74-225-208(219)220)175(300)241-128(57-66-156(282)283)182(307)261-160(105(18)19)199(324)257-138(84-103(14)15)187(312)242-127(56-65-155(280)281)178(303)244-130(69-77-332-28)172(297)230-109(23)165(290)232-119(46-38-72-223-206(215)216)170(295)228-110(24)166(291)234-125(54-63-153(276)277)177(302)240-124(53-62-151(213)274)180(305)248-133(79-98(4)5)184(309)231-111(25)167(292)233-123(52-61-150(212)273)176(301)239-122(51-60-149(211)272)171(296)229-112(26)168(293)247-141(87-115-91-221-96-226-115)192(317)259-145(94-269)196(321)255-143