86786-24-5

Basic information

• Product Name: 2-Bromo-5-isopropoxytoluene
• Synonyms: 2-Bromo-5-isopropoxytoluene;1-bromo-2-methyl-4-(propan-2-yloxy)benzene
• CAS NO: 86786-24-5
• Molecular Formula: C₁₀H₁₃BrO
• Molecular Weight: 229.11362
• Mol File: 86786-24-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Bromo-5-isopropoxytoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-isopropoxytoluene(86786-24-5)
• EPA Substance Registry System: 2-Bromo-5-isopropoxytoluene(86786-24-5)

Safety Data

• Hazardous Substances Data: 86786-24-5(Hazardous Substances Data)

Upstream product

• 14472-14-1 4-bromo-3-methylphenol 
• 75-26-3 isopropyl bromide 
• 19177-04-9 1-isopropoxy-3-methylbenzene 

Downstream Products

• 86786-26-7 4-isopropoxy-2-methylcinnamic acid 
• 86786-25-6 4-isopropoxy-2-methylbenzaldehyde 

Relevant articles and documents

New pyrrolidine derivatives, pharmaceutical compositions and uses thereof

Pyrrolidine derivatives of the formula and their use as medicaments for the treatment of obesity and type 2 diabetes.

Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase

Acetyl-CoA carboxylase (ACC) is a target of interest for the treatment of metabolic syndrome. Starting from a biphenyloxadiazole screening hit, a series of piperazine oxadiazole ACC inhibitors was developed. Initial pharmacokinetic liabilities of the piperazine oxadiazoles were overcome by blocking predicted sites of metabolism, resulting in compounds with suitable properties for further in vivo studies. Compound 26 was shown to inhibit malonyl-CoA production in an in vivo pharmacodynamic assay and was advanced to a long-term efficacy study. Prolonged dosing with compound 26 resulted in impaired glucose tolerance in diet-induced obese (DIO) C57BL6 mice, an unexpected finding.