86798-59-6

Usage

InChI:InChI=1/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)

Upstream product

• 88427-81-0 4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid 
• 86798-58-5 α-<4-(1H-imidazol-1-yl)phenyl>-4-morpholineacetonitrile 
• 110-91-8 morpholine 
• 4786-20-3 crotononitrile 
• 10040-98-9 1-(4-formylphenyl)-1H-imidazole 
• 97150-78-2 2-<4-(1H-imidazol-1-yl)phenyl>-3-methyl-2-(4-morpholinyl)pentanedinitrile 
• 88427-89-8 4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanenitrile 

Downstream Products

• 86798-76-7 6-<4-(1H-imidazol-1-yl)phenyl>-5-methyl-3(2H)-pyridazinone 

Relevant academic research and scientific papers

4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and pharmaceutical compositions containing the compounds as active components

A novel method of producing 4,5-dihydro-6-(substituted)phenyl-5-methyl-3(2H)-pyridazinone compounds and the corresponding pharmaceutically acceptable salt compounds is provided as well as pharmaceutical compositions containing one or more of the compounds

Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones

Substituted 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinone compounds and 6-(substituted)phenyl-3(2H)-pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents. Said compounds cause a significant increase in myocardial contractility in the dog. Said compounds also cause a decrease in blood pressure in the spontaneously hypertensive rat. Said compounds are produced by reacting substituted γ-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinones which are dehydrogenated to 6-(substituted)phenyl-3(2H)-pyridazinones. Both the intermediate 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinones and the 6-(substituted)phenyl-3(2H)-pyridazinones are useful as cardiotonic and antihypertensive agents.

Cardiotonic Agents. 2. Synthesis and Structure-Activity Relationships of 4,5-Dihydro-6--3(2H)-pyridazinones: A New Class of Positive Inotropic Agents

A series of 4,5-dihydro-6--3(2H)-pyridazinones and related compounds were synthesized and evaluated for positive inotropic activity.Most members of this series produced dose-related increases in myocardial contractility that we

Method of treating high blood pressure using 6-[4-(1-imidazolyl)-phenyl]-5-methyl-3-oxo-tetrahydropyridazines

The present invention relates to new 6-[Imidazolyl-phenyl]-5-methyl-3-oxo-tetrahydropyridazines of the general formula I STR1 as well as their acid addition salts, methods for their use, and pharmaceutical preparations containing them.