86798-76-7

Upstream product

• 97150-78-2 2-<4-(1H-imidazol-1-yl)phenyl>-3-methyl-2-(4-morpholinyl)pentanedinitrile 
• 88427-89-8 4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanenitrile 
• 10040-98-9 1-(4-formylphenyl)-1H-imidazole 
• 86798-59-6 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-3(2H)-pyridazinone 
• 86798-58-5 α-<4-(1H-imidazol-1-yl)phenyl>-4-morpholineacetonitrile 
• 88427-81-0 4-(1H-imidazol-1-yl)-β-methyl-γ-oxobenzenebutanoic acid 

Relevant academic research and scientific papers

Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones

Substituted 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinone compounds and 6-(substituted)phenyl-3(2H)-pyridazinone compounds and pharmaceutically acceptable salts thereof are useful as cardiotonic and antihypertensive agents. Said compounds cause a significant increase in myocardial contractility in the dog. Said compounds also cause a decrease in blood pressure in the spontaneously hypertensive rat. Said compounds are produced by reacting substituted γ-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinones which are dehydrogenated to 6-(substituted)phenyl-3(2H)-pyridazinones. Both the intermediate 4,5-dihydro-6-(substituted)phenyl-3(2H)-pyridazinones and the 6-(substituted)phenyl-3(2H)-pyridazinones are useful as cardiotonic and antihypertensive agents.

Cardiotonic Agents. 2. Synthesis and Structure-Activity Relationships of 4,5-Dihydro-6--3(2H)-pyridazinones: A New Class of Positive Inotropic Agents

A series of 4,5-dihydro-6--3(2H)-pyridazinones and related compounds were synthesized and evaluated for positive inotropic activity.Most members of this series produced dose-related increases in myocardial contractility that we