868049-49-4 Usage
Description
6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one, also known as olodaterol, is a member of the benzoxazine class of compounds. It is a potent and highly selective β2-adrenergic receptor agonist with a rapid onset of action and bronchoprotection over 24 hours. Olodaterol forms a highly stable complex with the β2-adrenergic receptor, with a dissociation half-life of 17.8 hours. It is used for the long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.
Uses
Used in Pharmaceutical Industry:
Olodaterol is used as a bronchodilator for the long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. It is delivered via the Respimat Soft Mist inhaler and has been approved for use in Russia, Canada, and the European Union.
Used in Drug Synthesis:
The synthesis of olodaterol proceeds through an (R)-styrene epoxide that is prepared via enantioselective reduction of an α-chloroketone intermediate. Ring opening of the epoxide with 1-(4-methoxyphenyl)-2-methylpropan-2-amine provides olodaterol. This synthesis process is used in the pharmaceutical industry to produce olodaterol for medical use.
Originator
Boehringer-Ingelheim (European Union)
Check Digit Verification of cas no
The CAS Registry Mumber 868049-49-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,8,0,4 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 868049-49:
(8*8)+(7*6)+(6*8)+(5*0)+(4*4)+(3*9)+(2*4)+(1*9)=214
214 % 10 = 4
So 868049-49-4 is a valid CAS Registry Number.
868049-49-4Relevant articles and documents
Olodaterol hydrochloride crystal form A and preparation method thereof
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, (2019/01/16)
The invention relates to a long-acting beta 2 adrenergic agonist drug olodaterol hydrochloride crystal form A, a preparation method thereof and and a pharmaceutical composition containing the crystalform A. The crystal form is characterized by X-ray diffr
PROCESS FOR THE MANUFACTURING OF BETAMIMETICS
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Page/Page column 12, (2008/06/13)
The present invention relates to a process for preparing betamimetics of formula 1, wherein n denotes 1 or 2; R1 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 denotes hydrogen, halogen, C1-4/su
NOVEL ENANTIOMERICALLY PURE BETA-AGONISTS, METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF A DRUG
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Page/Page column 22, (2008/06/13)
The invention relates to enantiomerically pure compounds of formula (1), wherein the radicals R1, R2, R3, R4and X are defined as in claims and a description. A method for producing said compounds and the use thereof