869478-13-7

Usage

Uses

Used in Pharmaceutical Industry:
8-[(1R)-1-Hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one is used as an intermediate in the synthesis of Olodaterol (O262000), a long-acting β-adrenoceptor agonist. This medication is administered as an inhalation treatment for patients with chronic obstructive pulmonary disease (COPD). 8-[(1R)-1-Hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one's unique structure allows it to target and activate β-adrenergic receptors in the lungs, leading to bronchodilation and improved respiratory function.
Used in Chemical Research:
8-[(1R)-1-Hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one is also utilized in chemical research for the development of new pharmaceuticals and agrochemicals. Its complex structure and functional groups make it a valuable starting material for the synthesis of novel compounds with potential applications in various fields, such as medicine, agriculture, and materials science.

Upstream product

• 869478-11-5 6-benzyloxy-8-((R)-2-chloro-1-hydroxyethyl)-4H-benzo[1,4]-oxazin-3-one 
• 869478-12-6 8-(2R)-oxirane-6-(phenylmethoxy)-2H-1,4-benzoxazine-3(4H)-one 
• 56490-94-9 1-(2-amino-2-methylpropyl)-4-methoxybenzene 

Downstream Products

• 868049-49-4 (R)-6-hydroxy-8-{(1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl}-4H-1,4-benzoxazin-3-one 
• 869477-96-3 Olodaterol hydrochloride 
• 869477-96-3 6-hydroxy-8-{(1R)-1-hydroxy-2-{[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino}ethyl}-4H-[1,4]benzoxazin-3-one hydrochloride 

Relevant academic research and scientific papers

Olodaterol hydrochloride crystal form A and preparation method thereof

The invention relates to a long-acting beta 2 adrenergic agonist drug olodaterol hydrochloride crystal form A, a preparation method thereof and and a pharmaceutical composition containing the crystalform A. The crystal form is characterized by X-ray diffr

Crystal form C of olodaterol hydrochloride and preparation method thereof

The invention relates to a crystal form C of a long-acting beta2 adrenergic agonist olodaterol hydrochloride and a preparation method thereof and a pharmaceutical composition containing the crystal form C. The crystal form is represented by the characteri

Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24 h bronchodilatory efficacy

Compound 4p was identified from a series of 6-hydroxy-4H-benzo[1,4]oxazin-3-ones as potent agonist of the human β2-adrenoceptor with a high β1/β2-selectivity. A complete reversal of acetylcholine-induced bronchoconstrictio

New enentiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments

The present invention relates to enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4 and X? may have the meanings given in the claims and in the specification, proce

NOVEL ENANTIOMERICALLY PURE BETA-AGONISTS, METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF A DRUG

The invention relates to enantiomerically pure compounds of formula (1), wherein the radicals R1, R2, R3, R4and X are defined as in claims and a description. A method for producing said compounds and the use thereof