868056-91-1Relevant academic research and scientific papers
Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092
Barton, Patrick,Caffrey, Moya V.,Linannen, Tero,Luckhurst, Christopher A.,Mochel, Tobias,Perry, Matthew W. D.,Springthorpe, Brian,Stein, Linda,Bahl, Ash,Bowers, Keith,Gilmour, Peter,Hawley, Shaun,Denton, Rebecca,Riley, Robert J.,Roe, Emma,Webborn, Peter
, p. 6694 - 6699,6 (2012)
The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.
