868074-72-0Relevant academic research and scientific papers
Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7- dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase
Cushman, Mark,Jin, Guangyi,Illarionov, Boris,Fischer, Markus,Ladenstein, Rudolf,Bacher, Adelbert
, p. 8162 - 8170 (2005)
The last two steps in the biosynthesis of riboflavin, an essential metabolite that is involved in electron transport, are catalyzed by lumazine synthase and riboflavin synthase. To obtain structural probes and inhibitors of these two enzymes, two ribityll
