868142-46-5

Basic information

• Product Name: 8-(4-hydroxy-phenyl)-2,4-dioxo-1,3-diaza-spiro[4.5]decane-1,3-dicarboxylic acid di-tert-butyl ester
• CAS NO: 868142-46-5
• Molecular Weight: 460.527
• Mol File: 868142-46-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-(4-hydroxy-phenyl)-2,4-dioxo-1,3-diaza-spiro[4.5]decane-1,3-dicarboxylic acid di-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(4-hydroxy-phenyl)-2,4-dioxo-1,3-diaza-spiro[4.5]decane-1,3-dicarboxylic acid di-tert-butyl ester(868142-46-5)
• EPA Substance Registry System: 8-(4-hydroxy-phenyl)-2,4-dioxo-1,3-diaza-spiro[4.5]decane-1,3-dicarboxylic acid di-tert-butyl ester(868142-46-5)

Safety Data

• Hazardous Substances Data: 868142-46-5(Hazardous Substances Data)

Upstream product

• 142256-87-9 4-(1,4-dioxaspiro[4.5]decan-8-yl)phenol 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 868142-16-9 8-(4-hydroxy-phenyl)-1,3-diaza-spiro[4.5]decane-2,4-dione 
• 24424-99-5 di-tert-butyl dicarbonate 
• 105640-07-1 4-(4-hydroxyphenyl)cyclohexan-1-one 
• 868141-45-1 8-(4-hydroxy-phenyl)-1,4-dioxa-spiro[4.5]decan-8-ol 

Relevant articles and documents

Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides

Linear pentapeptides (Penta-cis-Apc-DPhe-Arg-Trp-Gly-NH2) containing 1-amino-4-phenylcyclohexane-1-carboxylic acid (cis-Apc) and substituted Apc are potent hMC4R agonists and they are inactive or weakly active in hMC1R, hMC3R, and hMC5R agonist assays. This study, together with our earlier report on 5-BrAtc, demonstrated the importance of replacing His 6 with phenyl-containing rigid templates in achieving good hMC4R agonist potency and selectivity against hMC1R in linear pentapeptides.