868156-49-4

Basic information

• Product Name: 4'-hydroxymethyl-2-hydroxy-2-methyl-1-phenyl-1-propan-1-one
• Synonyms: 4'-hydroxymethyl-2-hydroxy-2-methyl-1-phenyl-1-propan-1-one
• CAS NO: 868156-49-4
• Molecular Weight: 194.23
• Mol File: 868156-49-4.mol

Chemical Properties

• CAS DataBase Reference: 4'-hydroxymethyl-2-hydroxy-2-methyl-1-phenyl-1-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-hydroxymethyl-2-hydroxy-2-methyl-1-phenyl-1-propan-1-one(868156-49-4)
• EPA Substance Registry System: 4'-hydroxymethyl-2-hydroxy-2-methyl-1-phenyl-1-propan-1-one(868156-49-4)

Safety Data

• Hazardous Substances Data: 868156-49-4(Hazardous Substances Data)

Upstream product

• 63678-09-1 2-methyl-2-((tetrahydro-2H-pyran-2-yl)oxy)propanenitrile 
• 17100-68-4 2-((4-bromobenzyl)oxy)tetrahydro-2H-pyran 
• 868156-56-3 1-(4-bromomethyl-phenyl)-2-hydroxy-2-methyl-propan-1-one 
• 868156-48-3 2-bromo-1-(4-(bromomethyl)phenyl)-2-methylpropan-1-one 
• 14289-68-0 2-bromo-2-methyl-1-(4-methylphenyl)-1-propanone 

Downstream Products

• 868156-59-6 {6-[4-(2-hydroxy-2-methyl-propionyl)-benzyloxycarbonylamino]-hexyl}-carbamic acid 4-(2-hydroxy-2-methyl-propionyl)-benzyl ester 

Relevant articles and documents

A Benzophenone-Based Photocaging Strategy for the N7 Position of Guanosine

Selective modification of nucleobases with photolabile caging groups enables the study and control of processes and interactions of nucleic acids. Numerous positions on nucleobases have been targeted, but all involve formal substitution of a hydrogen atom with a photocaging group. Nature, however, also uses ring-nitrogen methylation, such as m7G and m1A, to change the electronic structure and properties of RNA and control biomolecular interactions essential for translation and turnover. We report that aryl ketones such as benzophenone and α-hydroxyalkyl ketone are photolabile caging groups if installed at the N7 position of guanosine or the N1 position of adenosine. Common photocaging groups derived from the ortho-nitrobenzyl moiety were not suitable. Both chemical and enzymatic methods for site-specific modification of N7G in nucleosides, dinucleotides, and RNA were developed, thereby opening the door to studying the molecular interactions of m7G and m1A with spatiotemporal control.

A photoinitiator 4' - hydroxy methyl -2 - hydroxy -2 - methyl -1 - phenyl -1 - propyl ketone preparation method

The invention relates to a preparation method for a photoinitiator 4minute-hydroxymethyl-2-hydroxyl-2-methyl-1-phenyl-1-propyl ketone. The preparation method comprises the following steps of reacting 2-hydroxyl-2-methyl-1-phenyl-1-propyl ketone with paraformaldehyde to generate 4minute-chloromethyl-2-hydroxyl-2-methyl-1-phenyl-1-propyl ketone under the condition that aluminum trichloride is employed as a catalyst and dichloroethane is employed as a solvent, controlling temperature to be 90 to 100 DEG C, reacting 4minute-chloromethyl-2-hydroxyl-2-methyl-1-phenyl-1-propyl ketone with water to obtain 4minute-hydroxymethyl-2-hydroxyl-2-methyl-1-phenyl-1-propyl ketone, wherein the purity of a liquid phase reaches 99.21 percent. The preparation method is easy to operate, a process is advanced, the solvent can be recycled, and easiness in industrial production is ensured.

NEW PHOTOINITIATORS

The invention relates to novel photoinitators of formulae (I), (II), (III), (IV), (V) and (VI) wherein R1 and R2 are each independently of the other C1-C8alkyl; C1-C4alkyl substituted by OH, C1-C4alkoxy, -COO(C1-C8alkyl), (C1-C4alkyl)-COO-, -CN, benzyl, phenyl or by -N(R15)(R16); C3-C6alkerlyl, benzyl, -CH2-C6H4-(C1-C4alkyl) or phenyl; or R1 and R2 together are unbrarched or branched C2-C9alkylene or C3-C6-oxa- or -aza-alkylene; R3, R4, R5 and R6 are each independently of the others hydrogen, C1-C8alkyl, C3-C6alkenyl, benzyl, -CH2-C6H4-(C1-C4alkyl) or phenyl; R3 and R4 together and/or R5 and R6 together are unbranched or branched C2-C9alkylene; A is CI, Br, -O-R9, -N(R11)(R12) or -S-R18, A' is -O-, -NH- or -NR11-; A" is CI, Br, -O-R9, -N(R11)(R12) or -S-R18 or hydrogen, X is -O-R10 or -N(R13)(R14), n is an integer from 1 to 10, preferably an integer from 1 to 4, especially 1, 2 or 3; R7 is a linker; R8 is a bivalent C2-C3alkylele radical.