86818-89-5Relevant academic research and scientific papers
Synthesis of 2-Aryl-1-(4-morpholinophenyl)-4-(3,4-disubstituted-benzylidene)imidazolin-5-ones as CNS Active Agents
Agarwal, Rajesh,Chaudhary, Chapla,Misra, V. S.
, p. 308 - 310 (2007/10/02)
The title compounds (IVa-l) have been prepared by the action of p-morpholinoaniline (II) on appropriate oxazolin-5-ones (III) in the presence of anhyd.ZnCl2 or super dry pyridine.However, the interaction of II and III in ordinary pyridine/benzene or in the absence of anhydr.ZnCl2 gives p-morpholinophenylcarboxamides (V) of α-arylcarboxamido-β-(3,4-disubstituted phenyl)acrylic acids indicating the reaction of II and III to be moisture sensitive.Compounds IV have been found to be nontoxic and psychotropic.
