868262-39-9Relevant academic research and scientific papers
Discovery and SAR studies of novel GlyT1 inhibitors
Walter, Magnus W.,Hoffman, Beth J.,Gordon, Kimberly,Johnson, Kirk,Love, Patrick,Jones, Matthew,Man, Teresa,Phebus, Lee,Reel, Jon K.,Rudyk, Helene C.,Shannon, Harlan,Svensson, Kjell,Yu, Hong,Valli, Matthew J.,Porter, Warren J.
, p. 5233 - 5238 (2008/03/14)
Inhibition of the glycine transporter GlyT1 is a potential strategy for the treatment of schizophrenia. A novel series of GlyT1 inhibitors and their structure-activity relationships (SAR) are described. Members of this series are highly potent and selective transport inhibitors which are shown to elevate glycine levels in cerebrospinal fluid.
2-ARYLOXYETHYL GLYCINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORT INHIBITORS
-
Page/Page column 54, (2010/02/14)
The present invention relates to certain 2-aryloxyethyl glycine derivatives that exhibit activity as inhibitors of the glycine type-1 transporter, to pharmaceutical compositions containing them and to their use in the treatment of neurological and neuropsychiatric disorder.
