868274-66-2Relevant academic research and scientific papers
Hydroxyethylene sulfones as a new scaffold to address aspartic proteases: Design, synthesis, and structural characterization
Specker, Edgar,B?ttcher, Jark,Heine, Andreas,Sotriffer, Christoph A.,Lilie, Hauke,Schoop, Andreas,Müller, Gerhard,Griebenow, Nils,Klebe, Gerhard
, p. 6607 - 6619 (2007/10/03)
Hydroxyethylene sulfones were developed as novel scaffolds against aspartyl proteases. A diastereoselective synthesis has been established to introduce the required side chain decoration with desired stereochemistry. Depending on the substitution of the h
