868372-54-7

Upstream product

• 54004-20-5 2-amino-4-hydroxy-6-methylaminopyrimidine 
• 58047-52-2 2-(2,4,6-trimethylphenyl)acetaldehyde 
• 6950-92-1 2-(2,4,6-trimethylphenyl)ethanol 
• 868372-53-6 2-amino-5-mesityl-7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 
• 77-78-1 dimethyl sulfate 
• 1219828-99-5 C₁₁H₁₃BrO 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Discovery of pyrrolo[2,3-d]pyrimidin-4-ones as corticotropin-releasing factor 1 receptor antagonists with a carbonyl-based hydrogen bonding acceptor

A new class of pyrrolo[2,3-d]pyrimidin-4-one corticotropin-releasing factor 1 (CRF1) receptor antagonists has been designed and synthesized. In general, reported CRF1 receptor antagonists possess a sp 2-nitrogen atom as hy

CYCLIC COMPOUNDS

There is provided a CRF receptor antagonist comprising a compound of the formula (I): A-W-Ar wherein, A is a group represented by the formula (A1) or (A2) (wherein, ring Aa is a 5-or 6-membered ring which may be further substituted; ring Ab is a 5-or 6-membered ring which may be further substituted; ring Ac is a 5- or 6-membered ring which may be substituted; R1 is optionally substituted alkyl, substituted amino, substituted hydroxy, etc.; X is carbonyl, -O-, -S-, etc.; Y1, Y2 and Q are independently optionally substituted carbon or nitrogen; … is a single or double bond); W is a bond, optionally substituted methylene, optionally substituted imino, -O-, -S-, etc.; Ar is optionally substituted aryl or optionally substituted heteroaryl; or a salt thereof or a prodrug thereof.