86843-98-3Relevant academic research and scientific papers
PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE
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, (2022/04/22)
Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with Helios and which may benefit from Helios degradation.
Synthetic method 1, 2 and 4 - triazole compound
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Paragraph 0058-0061, (2021/12/07)
The invention discloses 1. 2,4 - Triazole compound synthesis method belongs to the technical field of synthesis of triazole compounds. After the reaction is finished, the reaction is carried out under the heating condition, and the target product 1, 2 and
A Convenient Synthesis of 1,5-Fused 1,2,4-Triazoles from N-Arylamidines via Chloramine-T Mediated Intramolecular Oxidative N-N Bond Formation
Bhatt, Ashish,Kant, Ravi,Sarma, Bhupendra K.,Singh, Rajesh K.
, p. 3883 - 3890 (2019/10/11)
A convenient synthesis of 1,5-fused 1,2,4-triazoles from readily available N-arylamidines is reported. The reaction is efficiently promoted by chloramine-T to afford the desired products mostly in high yields and in relatively short time, through direct m
Trichloroisocyanuric acid-mediated synthesis of 1,5-fused 1,2,4-triazoles from N-heteroaryl benzamidines via intramolecular oxidative N–N bond formation
Bhatt, Ashish,Singh, Rajesh K.,Sarma, Bhupendra K.,Kant, Ravi
supporting information, (2019/08/13)
A convenient synthesis of 1,5-fused 1,2,4-triazoles from readily available N-heteroaryl benzamidines is reported. The reaction is efficiently promoted by trichloroisocyanuric acid to afford the desired products, mostly in high yields and in relatively sho
Anthracene-based organic electroluminescent electron transport compound and light-emitting apparatus thereof
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Paragraph 0044; 0045; 0046, (2017/07/12)
The invention provides an anthracene-based organic electroluminescent electron transport compound. The compound has relatively good heat stability, high light-emitting efficiency and high light-emitting purity, can be used for manufacturing an organic electroluminescent apparatus, and is applied to the field of the organic electroluminescent apparatus, an organic solar battery, an organic film transistor or an organic photoreceptor. The invention also provides the organic electroluminescent apparatus which comprises an anode, a cathode and an organic layer; the organic layer comprises at least one of a light-emitting layer, a cavity injection layer, a cavity transport layer, a cavity barrier layer, an electron injection layer and an electron transport layer, and the at least one of the organic layers comprises a compound as shown in a structural formula I in the description.
Organic electroluminescence compound containing carbazole derivative and light emitting device thereof
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Paragraph 0108; 0109; 0110, (2017/08/29)
The invention provides an organic electroluminescence compound containing a carbazole derivative. The organic electroluminescence compound has better heat stability, high light emitting efficiency and high light emitting purity, and can be used for manufacturing organic electroluminescence devices, and applied into fields of organic solar batteries, organic thin film transistors or organic light sensors. The invention also provides the organic electroluminescence device, and the organic electroluminescence device comprises an anode, a cathode and an organic layer, wherein the organic layer comprises at least one of a light emitting layer, a cavity injection layer, a cavity transmission layer, a cavity blocking layer, an electron injection layer, and an electron transmission layer; the organic layer at least comprises a compound containing the carbazole derivative with a structure formula I; the structure formula I is shown in the description.
I2/KI-Mediated Oxidative N-N Bond Formation for the Synthesis of 1,5-Fused 1,2,4-Triazoles from N -Aryl Amidines
Song, Lina,Tian, Xianhai,Lv, Zhigang,Li, Ertong,Wu, Jie,Liu, Yangxue,Yu, Wenquan,Chang, Junbiao
, p. 7219 - 7225 (2015/07/28)
An I2/KI-mediated oxidative N-N bond formation reaction is described. This new and environmentally benign approach allows for the convenient synthesis of a variety of 1,2,4-triazolo[1,5-a]pyridines and other 1,5-fused 1,2,4-triazoles from readi
PhI(OCOCF3)2-mediated intramolecular oxidative N-N bond formation: Metal-free synthesis of 1,2,4-triazolo[1,5-a]pyridines
Zheng, Zisheng,Ma, Shuangyu,Tang, Linlin,Zhang-Negrerie, Daisy,Du, Yunfei,Zhao, Kang
, p. 4687 - 4693 (2014/06/09)
The biologically important 1,2,4-triazolo[1,5-a]pyridines were readily synthesized from N-(pyridin-2-yl)benzimidamides via phenyliodine bis(trifluoroacetate)-mediated intramolecular annulation. This novel strategy allows for the convenient construction of a 1,2,4-triazolo[1,5-a]pyridine skeleton through direct metal-free oxidative N-N bond formation, featuring a short reaction time and high reaction yields.
PROCESS FOR THE PREPARATION OF 2-PHENYL-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE DERIVATIVES
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Paragraph 0089; 0090; 0091; 0092, (2014/12/09)
The invention relates to a novel process for the preparation of 2-phenyl-[1,2,4]triazolo[1,5-a]pyridine derivatives of formula I or of a salt thereof wherein R1 stands for hydrogen, a halogen, for an optionally protected hydroxyl group or for an optionally protected amino group and R2 is hydrogen or a halogen. 2-Phenyl-[1,2,4]triazolo[1,5-a]pyridine derivatives of formula I with their 1,2,4-triazole nucleus build the structural core of a great number of functionalized molecules in medicinal chemistry.
TRIAZOLOPYRIDINE COMPOUNDS AS PDE10A INHIBITORS
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Page/Page column 25, (2013/04/10)
The invention is concerned with triazolopyridine compounds of formula (I) wherein R1, R2 and R3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhi
