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868594-43-8

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868594-43-8 Usage

General Description

Benzyl-PEG7-amino is a chemical compound composed of a benzyl group, a polyethylene glycol (PEG) chain with seven ethylene glycol units, and an amino group. It is often used as a precursor in the synthesis of various pharmaceuticals, drug delivery systems, and other biomedical applications. The PEG chain provides solubility and stability to the compound, while the amino group allows for easy conjugation with other molecules or surfaces. Benzyl-PEG7-amino is also known for its biocompatibility and low toxicity, making it a popular choice for use in biological and medical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 868594-43-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,8,5,9 and 4 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 868594-43:
(8*8)+(7*6)+(6*8)+(5*5)+(4*9)+(3*4)+(2*4)+(1*3)=238
238 % 10 = 8
So 868594-43-8 is a valid CAS Registry Number.

868594-43-8Downstream Products

868594-43-8Relevant articles and documents

Synthesis of bifunctional integrin-binding peptides containing PEG spacers of defined length for non-viral gene delivery

Pilkington-Miksa, Michael A.,Sarkar, Supti,Writer, Michele J.,Barker, Susie E.,Shamlou, Parviz Ayazi,Hart, Stephen L.,Hailes, Helen C.,Tabor, Alethea B.

experimental part, p. 2900 - 2914 (2009/04/11)

Improving the buffer and serum stability of non-viral gene delivery vectors, and increasing their circulation time in vivo, is an important focus of current research in gene therapy. The most successful strategies to date have involved shielding the complexes with large polydisperse PEG adducts. However, this approach is accompanied by a fall in transfection efficiency. In this paper we describe the solid-phase synthesis of a series of bifunctional peptides bearing short PEG spacers of defined structure as components of lipopolyplex gene delivery vectors. Short, high-yielding routes to a series of PEG-amino acids are described: these PEG-amino acids can be used in varying combinations to afford bifunctional peptides with varying lengths of PEG spacers by using standard solid-phase synthesis techniques. A series of lipopolyplexes were formulated using these bifunctional peptides, and their transfection properties assessed. Dynamic light scattering measurements on the complex with the best transfection properties showed that in phosphate-buffered saline this complex was considerably more stable, and aggregated more slowly, than a complex formulated using a similar peptide lacking the short PEG spacer. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

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