868614-26-0

Basic information

• Product Name: 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetic acid
• Synonyms: 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetic acid
• CAS NO: 868614-26-0
• Molecular Weight: 222.265
• Mol File: 868614-26-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetic acid(868614-26-0)
• EPA Substance Registry System: 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetic acid(868614-26-0)

Safety Data

• Hazardous Substances Data: 868614-26-0(Hazardous Substances Data)

Upstream product

• 108-98-5 thiophenol 
• 745052-94-2 ethyl 2-(4-cyclopropylsulfanylphenyl)-2-oxoacetate 

Downstream Products

• 1328995-70-5 4-[[2-[[2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluorophenoxy)acetyl]amino]thiazol-5-yl]methyl]benzoic acid 
• 1328995-86-3 1-[[2-[[2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluorophenoxy)acetyl]amino]thiazol-5-yl]methyl]piperidine-4-carboxylic acid 
• 1328995-53-4 3-[2-[[2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluorophenoxy)acetyl]amino]thiazol-5-yl]prop-2-ynoic acid 
• 1328995-50-1 2-[4-[2-[[2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluorophenoxy)acetyl]amino]thiazol-5-yl]oxyphenyl]acetic acid 
• 1328994-82-6 3-[2-[[2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluorophenoxy)acetyl]amino]thiazol-5-yl]oxybenzoic acid 
• 1328984-99-1 methyl 2-[4-[2-[[2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluorophenoxy)acetyl]amino]thiazol-5-yl]oxyphenyl]acetate 
• 1328984-60-6 methyl 3-[2-[[2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluorophenoxy)acetyl]amino]thiazol-5-yl]oxybenzoate 
• 1328983-37-4 methyl 4-[2-[[2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluorophenoxy)acetyl]amino]thiazol-5-yl]oxybenzoate 
• 1328985-59-6 4-{2-[2-(4-cyclopropanesulfonylphenyl)-2-(2,4-difluorophenoxy)acetylamino]thiazol-5-yloxy}benzoic acid 
• 1143510-49-9 2-(4-cyclopropanesulfonylphenyl)-2-(2,4-difluorophenoxy)acetic acid 
• 1080059-87-5 methyl 2-(4-cyclopropylsulfonylphenyl)acetate 
• 868614-27-1 2-(4-cyclopropylsulfanylphenyl)acetic acid 

Relevant articles and documents

Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia

Glucokinase activators (GKAs) are among the emerging drug candidates for the treatment of type 2 diabetes (T2D). Despite effective blood glucose lowering in clinical trials, many pan-GKAs “acting both in pancreas and liver” have been discontinued from cli

NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME

Compounds are provided which are glucokinase activators and thus are useful in treating diabetes and related diseases and have the structure wherein in the ring represents one or two double bonds; R1 is aryl or heteroaryl; R2 is halogen, cycloalkyl, heterocyclyl, aryl, or heteroaryl; R5 is as defined herein; Z is O, S, S(O), S(O)2, or NR5a; X is S, O, N, NR3, or CR3; Y is NCR4 or N4; R3, R4, and R5 are as defined herein; R8 is aryl or heteroaryl; R6 and R7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.

TRICYCLO SUBSTITUTED AMIDES AS GLUCOKINASE MODULATORS

Compounds of Formula (I): (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.

SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS

Compounds of Formula (I) wherein R1 is a cycloalkylsulphonyl group, or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.

FLUORINATION PROCESS OF PROTECTED AMINOTHIAZOLE

A process for the production of fluorinated compound formula (I) comprising fluorination of a protected aminothiazole. Compounds formula (I) are useful in the preparation of activators of glucokinase.

TRI(CYCLO) SUBSTITUTED AMIDE COMPOUNDS

Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.