868623-74-9Relevant academic research and scientific papers
Adamantane 11-β-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction
Sorensen, Bryan,Rohde, Jeff,Wang, Jiahong,Fung, Steven,Monzon, Katina,Chiou, William,Pan, Liping,Deng, Xiaoqing,Stolarik, DeAnne,Frevert, Ernst U.,Jacobson, Peer,Link
, p. 5958 - 5962 (2007/10/03)
A series of potent and selective adamantane aminoamide 11-β-HSD-1 inhibitors has been optimized. Chemically these studies were expedited by utilizing readily obtained amino acids as starting materials or an isocyanide multicomponent reaction. Structure-ac
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
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Page/Page column 42, (2010/02/14)
The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatme
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
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Page/Page column 29, (2008/06/13)
The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and other diseases and conditions that are mediated by excessive glucocorticoid action.
