868636-08-2Relevant academic research and scientific papers
Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs
Burke, Philip J.,Wong, Lai Chun,Jenkins, Terence C.,Knox, Richard J.,Meikle, Ian T.,Stanforth, Stephen P.
, p. 5851 - 5854 (2016/12/06)
A series of N-nitroarylated-3-chloromethyl-1,2,3,4-tetrahydroisoquinoline derivatives, several of which also possessed a trifluoromethyl substituent, were prepared and assessed as potential nitroaromatic prodrugs. The enzymatic reduction of these compound
Possible neighbouring group participation of a nitro-group in the conversion of 3-hydroxymethyl-2-(2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline into its 3-chloromethyl derivative
Donaghy, Michael J.,Stanforth, Stephen P.
, p. 1215 - 1218 (2007/10/03)
The alcohol 12 reacted with 4-toluenesulfonyl chloride in boiling dichloromethane solution to give the chlorinated product 13 rather than the expected tosylate 3 by a mechanism that could involve neighbouring group participation of the nitro-substituent.
