868662-32-2Relevant academic research and scientific papers
Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists
Dyck, Brian,Zhao, Liren,Tamiya, Junko,Pontillo, Joseph,Hudson, Sarah,Ching, Brett,Heise, Christopher E.,Wen, Jenny,Norton, Christi,Madan, Ajay,Schwarz, David,Wade, Warren,Goodfellow, Val S.
, p. 4237 - 4242 (2007/10/03)
A series of substituted chromones were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor 1. Compounds with subnanomolar binding affinity and 66% oral bioavailability in rats were discovered.
2- (3-AMINOPYRROLIDIN-1-YL) PYRIDINES AS MELANIN-CONCENTRATING HORMONE RECEPTOR AN TAGONISTS
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Page/Page column 54, (2010/02/14)
Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the following structure: including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R5, Het, X and Cyc are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.
