119776-15-7

Upstream product

• 100-39-0 benzyl bromide 
• 98619-07-9 1-(2-fluoro-4-hydroxyphenyl)ethanone 
• 54696-05-8 4'-benzyloxy-acetophenone 
• 121219-03-2 4-bromo-3-fluorophenol 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 185346-79-6 4-(benzyloxy)-1-bromo-2-fluorobenzene 
• 372-20-3 3-fluorophenol 

Downstream Products

• 850142-10-8 1-[4-(benzyloxy)-2-fluorophenyl]-2-bromoethanone 
• 1042702-55-5 C₂₄H₂₈FNO₆ 
• 1042702-57-7 C₂HF₃O₂*C₁₂H₁₄FNO₄ 
• 362512-26-3 6-Benzyloxy-3-methyl-1H-indazole 
• 868662-32-2 1-(4-benzyloxy-2-fluoro-phenyl)-2-[6-(3-dimethylamino-pyrrolidin-1-yl)-pyridin-3-yl]-ethanone 

Relevant academic research and scientific papers

Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib

The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.

P-Hydroxyphenacyl photoremovable protecting groups Robust photochemistry despite substituent diversity

A broadly based investigation of the effects of a diverse array of substituents on the photochemical rearrangement of p-hydroxyphenacyl esters has demonstrated that common substituents such as F, MeO, CN, CO2R, CONH2, and CH3 have little effect on the rate and quantum efficiencies for the photo-Favorskii rearrangement and the release of the acid leaving group or on the lifetimes of the reactive triplet state. A decrease in the quantum yields across all substituents was observed for the release and rearrangement when the photolyses were carried out in buffered aqueous media at pHs that exceeded the ground-state pKa of the chromophore where the conjugate base is the predominant form. Otherwise, substituents have only a very modest effect on the photoreaction of these robust chromophores.

PESTICIDAL SUBSTITUTED PHENYLETHERS

The invention relates to the use of phenylether derivatives of formula (I), to compositions thereof for the control of pests, including arthropods and helminths.

2- (3-AMINOPYRROLIDIN-1-YL) PYRIDINES AS MELANIN-CONCENTRATING HORMONE RECEPTOR AN TAGONISTS

Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the following structure: including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R5, Het, X and Cyc are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

6-hydroxy-indazole derivatives for treating glaucoma

Substituted 1-(α-alkyl-ethylamino)-1H-indazol-6-ols useful for lowering and controlling IOP and treating glaucoma are disclosed

P38 inhibitors and methods of use thereof

This invention relates to inhibitors of p38, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38.