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86867-01-8

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride, also known as SAM, is a vital methyl donor that plays a crucial role in numerous biological reactions, including those mediated by DNA and protein methyltransferases. The transfer of a methyl group from SAM to an acceptor results in the formation of S-adenosyl-L-homocysteine. Additionally, SAM is metabolized by SAM decarboxlase to produce decarboxylated SAM, which is involved in the polyamine pathway responsible for generating spermine. Cayman Chemical’s SAM is highly purified to eliminate all S-adenosylhomocysteine, a known inhibitor of most SAM-dependent methyltransferases, and contains no S-methylthioadenosine, a common impurity that may act as a substrate in some assay formats, leading to high background.

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  • 86867-01-8 Structure

  • Basic information

    1. Product Name: S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride
    2. Synonyms: S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride;SAM chloride dihydrochloride;5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine chloride dihydrochloride;S-(5'-Adenosyl)-L-methionine chloride (hydrochloride);-Adenosyl)-L-methionine chloride dihydrochloride
    3. CAS NO:86867-01-8
    4. Molecular Formula: C15H25Cl3N6O4S
    5. Molecular Weight: 491.8208
    6. EINECS: 246-184-8
    7. Product Categories: N/A
    8. Mol File: 86867-01-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: ?20°C
    8. Solubility: H2O: soluble100mg/mL
    9. BRN: 6560002
    10. CAS DataBase Reference: S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride(CAS DataBase Reference)
    11. NIST Chemistry Reference: S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride(86867-01-8)
    12. EPA Substance Registry System: S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride(86867-01-8)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 20/21/22-68/20/21/22
    3. Safety Statements: 36-45
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 86867-01-8(Hazardous Substances Data)

86867-01-8 Usage

Uses

Used in Biochemical Research:
S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride is utilized as a medium supplement for S30 cell extract, facilitating various cellular processes and reactions.
Used in Enzyme Interaction Studies:
In the pharmaceutical and biotechnology industries, SAM is employed for measuring the interaction with catechol-O-methyltransferase (COMT) through techniques such as quartz crystal microbalance (QCM), surface plasmon resonance (SPR), and isothermal titration calorimetry (ITC). These methods are essential for understanding enzyme dynamics and developing potential therapeutic agents.
Used in Supported Lipid Bilayers and Vesicles:
S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride is also used in the study of interactions with supported lipid bilayers and vesicles, which are crucial for mimicking cellular membranes and understanding the behavior of enzymes and other biomolecules in a cellular environment. This application is vital for advancing our knowledge of membrane biophysics and its implications in drug discovery and development.

Check Digit Verification of cas no

The CAS Registry Mumber 86867-01-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,8,6 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 86867-01:
(7*8)+(6*6)+(5*8)+(4*6)+(3*7)+(2*0)+(1*1)=178
178 % 10 = 8
So 86867-01-8 is a valid CAS Registry Number.

86867-01-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:86867-01-8 SDS

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