868692-62-0 Usage
Description
N-(4-Cyano-2-iodo-5-(trifluoromethyl)-phenyl)methanesulfonamide, also known as BAY 43-9006, is a chemical compound with potential anti-cancer properties. It is a kinase inhibitor that specifically targets and inhibits certain enzymes involved in cell growth and proliferation, making it a promising candidate for the treatment of various types of cancer.
Used in Pharmaceutical Industry:
N-(4-Cyano-2-iodo-5-(trifluoromethyl)-phenyl)methanesulfonamide is used as an anti-cancer agent for the treatment of advanced renal cell carcinoma and other solid tumors. Its mechanism of action involves the inhibition of both the Raf/MEK/ERK signaling pathway and the VEGFR/PDGFR signaling pathways, which are known to be dysregulated in cancer cells. BAY 43-9006 has been approved for use in the treatment of advanced kidney cancer and has shown potential for the treatment of other solid tumors as well.
Check Digit Verification of cas no
The CAS Registry Mumber 868692-62-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,8,6,9 and 2 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 868692-62:
(8*8)+(7*6)+(6*8)+(5*6)+(4*9)+(3*2)+(2*6)+(1*2)=240
240 % 10 = 0
So 868692-62-0 is a valid CAS Registry Number.
868692-62-0Relevant articles and documents
A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands
Lanter, James C.,Fiordeliso, James J.,Allan, George F.,Musto, Amy,Hahn, Do Won,Sui, Zhihua
, p. 5646 - 5649 (2007/10/03)
Two potential bioisosteres of the nonsteroidal antiandrogen bicalutamide, an imidazolidinone and an indole, were synthesized and tested for their androgen receptor binding. Indole was discovered to be a suitable bioisostere for the acyl anilide moiety in the parent compound. Several analogs in the indole series were found to be 10-fold better than bicalutamide in binding to the recombinant androgen receptor binding domain.
Novel indole derivatives as selective androgen receptor modulators (SARMS)
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Page/Page column 58-59, (2008/06/13)
The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
