868699-62-1Relevant academic research and scientific papers
Photoredox/Nickel Dual Catalysis Enables the Synthesis of Alkyl Cyclopropanes via C(sp3)-C(sp3) Cross Electrophile Coupling of Unactivated Alkyl Electrophiles
Dey, Purusattam,Jana, Sayan K.,Maiti, Mamata,Maji, Biplab
supporting information, p. 1298 - 1302 (2022/02/25)
A facile synthesis of mono-, 1,1- and 1,2-disubstituted cyclopropanes via visible light-mediated photoredox/nickel dual catalysis is demonstrated. The challenging intramolecular C(sp3)-C(sp3) cross-electrophile coupling of readily available unactivated 1,3-dialkyl electrophiles was performed under mild conditions that allowed traditionally reactive functional groups to be included. Mechanistic inspection and control experiments revealed the importance of dual catalysis and that the reaction proceeds via a stepwise oxidative addition followed by an intramolecular SN2 reaction.
An efficient synthesis of aryloxyphenyl cyclopropyl methanones: A new class of anti-mycobacterial agents
Dwivedi, Namrata,Tewari, Neetu,Tiwari,Chaturvedi, Vinita,Manju,Srivastava,Giakwad,Sinha,Tripathi
, p. 4526 - 4530 (2007/10/03)
An efficient, high yield and one-pot synthesis of phenyl cyclopropyl methanones by reaction of different aryl alcohols with 4′-fluoro-4-chloro- butyrophenone in THF/DMF in the presence of NaH/TBAB is reported. Most of the methanones were further reduced t
