877152-22-2Relevant academic research and scientific papers
Design and synthesis of novel 1, 3-dioxane-2-carboxylic acid derivatives as PPAR α/γ dual agonists
Pingali, Harikishore,Jain, Mukul,Shah, Shailesh,Makadia, Pankaj,Zaware, Pandurang,Jamili, Jeevankumar,Sairam, Kalapatapu V.V.M.,Patil, Pravin,Suthar, Dinesh,Giri, Suresh,Patel, Harilal,Patel, Pankaj
scheme or table, p. 421 - 429 (2011/10/09)
1,3-dioxane carboxylic acid derivatives were prepared based on our previous studies directed towards identifying novel pharmacophore for the development of PPAR α/γ dual agonists. Based on the typical topology of PPAR agonists we focused our design approa
Design and synthesis of novel oxazole containing 1,3-Dioxane-2-carboxylic acid derivatives as PPAR α/γ dual agonists
Pingali, Harikishore,Jain, Mukul,Shah, Shailesh,Makadia, Pankaj,Zaware, Pandurang,Goel, Ashish,Patel, Megha,Giri, Suresh,Patel, Harilal,Patel, Pankaj
, p. 7117 - 7127 (2008/12/22)
A few novel 1,3-dioxane carboxylic acid derivatives were designed and synthesized to aid in the characterization of PPAR α/γ dual agonists. Structural requirements for PPARα/γ dual agonism of 1,3-dioxane carboxylic acid derivatives included the structural
Modulation of PPAR receptor subtype selectivity of the ligands: Aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety
Pingali, Harikishore,Jain, Mukul,Shah, Shailesh,Patil, Pravin,Makadia, Pankaj,Zaware, Pandurang,Sairam, Kalapatapu V.V.M.,Jamili, Jeevankumar,Goel, Ashish,Patel, Megha,Patel, Pankaj
scheme or table, p. 6471 - 6475 (2009/10/01)
Oxazole containing glycine and oximinobutyric acid derivatives were synthesized as PPARα agonists by incorporating polymethylene spacer as a replacement of commonly used phenylene group that connects the acidic head with lipophilic tail. Compound 13a was
2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands
Lee, Jeewoo,Lee, Ju-Hyun,Kim, Su Yeon,Perry, Nicholas A.,Lewin, Nancy E.,Ayres, Jolene A.,Blumberg, Peter M.
, p. 2022 - 2031 (2007/10/03)
A series of 2-benzyl and 2-phenyl-3-hydroxypropyl pivalates designed to incorporate the principal pharmacophores of phorbol esters have been synthesized and tested as PKC-α ligands. Among the analogues, 13c exhibited the most potent binding affinity with a Ki = 0.7 μM. The synthesized analogues were subjected to molecular modeling analysis based on two alternative models of the phorbol pharmacophore and a docking study of 13c was carried out.
