890137-74-3

Upstream product

• 317319-09-8 (4-acetoxy-2-methylphenoxy)acetic acid methyl ester 
• 166953-80-6 (4-acetyl-2-methylphenoxy)acetic acid methyl ester 
• 317319-10-1 methyl (4-hydroxy-2-methylphenoxy)acetate 
• 868835-06-7 [4-(3,5-dibromobenzyloxy)-2-methylphenoxy]acetic acid methyl ester 
• 870289-02-4 [4-(5-bromo-4'-trifluoromethylbiphenyl-3-ylmethoxy)-2-methyl-phenoxy]acetic acid methyl ester 
• 139301-27-2 4-trifluoromethoxyphenylboronic acid 

Relevant academic research and scientific papers

1,3,5-Trisubstituted aryls as highly selective PPARδ agonists

A series of highly potent and selective PPARδ agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 μM, making it a useful tool in studying the biological effects of selective PPARδ activation.

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPARδ .