86885-57-6

Usage

Uses

Used in Organic Synthesis:
Trans Methyl 6-oxabicyclo[3.1.0]hexane-3-carboxylate is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique bicyclic structure and functional groups facilitate the formation of new chemical entities, contributing to the advancement of chemical research and development.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, trans Methyl 6-oxabicyclo[3.1.0]hexane-3-carboxylate is employed as a building block for the synthesis of pharmaceutical compounds. Its versatile structure allows for the development of new drugs with potential therapeutic applications, addressing unmet medical needs.
Used in Chemical Research and Development:
Trans Methyl 6-oxabicyclo[3.1.0]hexane-3-carboxylate is utilized as a research compound in chemical laboratories. Its unique structure and properties make it an interesting target for studying reaction mechanisms, exploring new synthetic routes, and discovering novel applications in various chemical fields.
Overall, trans Methyl 6-oxabicyclo[3.1.0]hexane-3-carboxylate is a valuable compound with diverse applications in organic synthesis, pharmaceuticals, and chemical research, showcasing its potential to contribute to the development of new chemical entities and therapeutic agents.

Upstream product

• 58101-60-3 methyl cyclopent-3-ene-1-carboxylate 

Downstream Products

• 174292-58-1 methyl (1S,3S)-3-hydroxycyclopentanecarboxylate 
• 366006-09-9 methyl (3R,4R)-3,4-dihydroxycyclopentanecarboxylate 
• 1214921-49-9 (1S,3S,4S)-methyl 3-fluoro-4-hydroxycyclopentanecarboxylate 
• 136522-33-3 (1S,4R)-4-[2-amino-6-chloro-9H-purin-9-yl]-2-cyclopentene-1-methanol 
• 852364-14-8 Toluene-4-sulfonic acid (1S,3S,5R)-1-(6-oxa-bicyclo[3.1.0]hex-3-yl)methyl ester 

Relevant academic research and scientific papers

3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

NITROOXY CYCLOALKANE DERIVATIVES

A compound having the structure wherein Y is selected from the group consisting of –C(O)OR2, -C(O)NHR8, -C(CH2)1-2OR3, OH, and or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.

ANGIOTENSIN II RECEPTOR ANTAGONISTS

A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is Y is selected from the group consisting of R1 is selected from the group consisting of —O—C1-6 alkyl,—O-aryl,—O-heteroaryl,—O—C3-8 cycloalkyl,—C1-6 alkyl,-aryl,-heteroaryl, and—C3-8 cycloalkyl; R2 and R3 are independently selected from the group consisting of hydrogen and C1-4 alkyl, or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

Carbocyclic 3′-deoxyadenosine-based highly potent bisubstrate-analog inhibitor of basophilic protein kinases

Carbocyclic analogs of 3′-deoxyadenosine were synthesized as racemates and the resulting stereoisomers were separated by chromatography on a chiral column. The conjugation of obtained compounds with hexa-(d-arginine) via 6-aminohexanoic acid linker led to a highly potent inhibitor of several basophilic protein kinases with some selectivity towards cAMP-dependent protein kinase.

Synthesis of carbocyclic phosphononucleosides

Syntheses of carbocyclic analogs of phosphononucleosides are described by two different methods (introduction of the heterocycle under Mitsunobu conditions or build-up of the base around a cyclopentylamine moiety).

An asymmetric synthesis of (-)-carbovir

Enantioselective deprotonation of trans-4-t-butyldimethylsiloxymetyl-1,2-epoxycyclopentane (trans-4) by a chiral lithium amide, lithium (S)-2-(pyrrolidin-1-ylmethyl)pyrrolidide (1), afforded (1S,4S)-trans-4-t-butyldimethylsiloxymethyl-2-cyclopenten-1-ol (trans-7) in 83% ee. Alcohol trans-7 was easily transformed to (-)-carbovir, an anti-HIV carbocyclic nucleoside.

Novel synthesis of (+/-)-cis-4-amino-2-cyclopentene-1-methanol, a key intermediate in the preparation of carbocyclic 2',3'-didehydro-2',3'-dideoxy nucleosides

Novel synthetic routes directed toward the preparation of (+/-)-cis-4-amino-2-cyclopentene-1-methanol are described. The routes investigated involve azide openings of chiral and non-chiral cyclopentyl epoxides.