852364-14-8Relevant academic research and scientific papers
Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon
Saito, Yoshio,Escuret, Vanessa,Durantel, David,Zoulim, Fabien,Schinazi, Raymond F.,Agrofoglio, Luigi A.
, p. 3633 - 3639 (2003)
The synthesis of carbocyclic and phosphonocarbocyclic analogues of ribavirin, an anti-HCV inhibitor, are described. Those compounds were evaluated against HCV but also against other important viruses in order to determine their spectrum of antiviral activity. Compounds 6 and 13 displayed a moderate IC50 against HIV-1 of 43.8 and 37 μM, respectively.
A flexible, efficient synthesis of (±)-carbocyclic phosphonic acid nucleoside derivatives
Wainwright, Phillip,Maddaford, Adrian,Bissell, Richard,Fisher, Ray,Leese, David,Lund, Andrew,Runcie, Karen,Dragovich, Peter S.,Gonzalez, Javier,Kung, Pei-Pei,Middleton, Donald S.,Pryde, David C.,Stephenson, Peter T.,Sutton, Scott C.
, p. 765 - 768 (2007/10/03)
An efficient and flexible synthesis of cyclopentane and hydroxylated cyclopentane phosphonic acid analogues is described. The key step involves the opening of an epoxide with either a nucleoside base or a selenyl anion to access the target molecules.
Synthesis of carbocyclic phosphononucleosides
Legeret,Sarakauskaite,Pradaux,Saito,Tumkevicius,Agrofoglio
, p. 661 - 664 (2007/10/03)
Syntheses of carbocyclic analogs of phosphononucleosides are described by two different methods (introduction of the heterocycle under Mitsunobu conditions or build-up of the base around a cyclopentylamine moiety).
