86886-82-0 Usage
General Description
N-(3,4-dichlorophenyl)-4-methylbenzamide is a chemical compound with a molecular formula of C14H11Cl2NO. It is a benzamide derivative that is commonly used as a pharmaceutical intermediate in the synthesis of various drugs and agrochemical products. N-(3,4-dichlorophenyl)-4-methylbenzamide is a white to off-white solid that is insoluble in water but soluble in organic solvents. N-(3,4-dichlorophenyl)-4-methylbenzamide has been shown to have potential biological and pharmacological activities, including analgesic and antipyretic properties. Its structure and properties make it a valuable and versatile tool in the field of medicinal chemistry and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 86886-82-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,8,8 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 86886-82:
(7*8)+(6*6)+(5*8)+(4*8)+(3*6)+(2*8)+(1*2)=200
200 % 10 = 0
So 86886-82-0 is a valid CAS Registry Number.
86886-82-0Relevant articles and documents
Design, synthesis and structure-activity relationship of new HSL inhibitors guided by pharmacophore models
Al-Shawabkeh, Jumana D.,Al-Nadaf, Afaf H.,Dahabiyeh, Lina A.,Taha, Mutasem O.
, p. 127 - 145 (2014/03/21)
Hormone-sensitive lipase (HSL) is a critical enzyme involved in the hormonally regulated release of fatty acids and glycerol from adipocyte lipid stores. Its inhibition may improve insulin sensitivity and blood glucose handling in type 2 diabetes. Accordingly, many small-molecule HSL inhibitors have recently been identified. In continuation of our efforts for discovery of new HSL inhibitors, we prepared a variety of esters, amides, sulfonamides and sulfonate esters capable of fitting two pharmacophore models that we developed and published earlier. The tested compounds were synthesized via coupling reactions of aroyl chlorides or sulfonyl chlorides with phenols, amines and related derivatives. Our efforts led to the identification of interesting compounds of low micromolar anti-HSL bioactivities, which have potential to be developed into effective antidiabetic agents.
