86896-38-0

Basic information

• Product Name: N-methyl-2-(4-methylphenyl)-2-oxo-N-phenylacetamide
• CAS NO: 86896-38-0
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.2958
• Mol File: 86896-38-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 393.7°C at 760 mmHg
• Flash Point: 170°C
• Density: 1.168g/cm³
• Vapor Pressure: 2.09E-06mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: N-methyl-2-(4-methylphenyl)-2-oxo-N-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-2-(4-methylphenyl)-2-oxo-N-phenylacetamide(86896-38-0)
• EPA Substance Registry System: N-methyl-2-(4-methylphenyl)-2-oxo-N-phenylacetamide(86896-38-0)

Safety Data

• Hazardous Substances Data: 86896-38-0(Hazardous Substances Data)

Upstream product

• 4294-57-9 para-methylphenylmagnesium bromide 
• 104-87-0 4-methyl-benzaldehyde 
• 36602-08-1 (N-methylanilino)acetonitrile 
• 94-08-6 4-methylbenzoic acid ethyl ester 
• 103245-08-5 p-methyl-α-(N-methylanilino)-β-hydroxy-cinnamonitrile 
• 66985-49-7 2-(4-methylphenyl)-2-(trimethylsilyloxy)acetonitrile 
• 34966-53-5 methyl 4-methylphenylglyoxylate 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 100-61-8 N-methylaniline 
• 121-69-7 N,N-dimethyl-aniline 

Relevant articles and documents

Silyl Cyanopalladate-Catalyzed Friedel-Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives

3-Aryloxindole derivatives were synthesized through a Friedel-Crafts-type cyclization. The reaction was catalyzed by a trimethylsilyl tricyanopalladate complex generated in situ from trimethylsilyl cyanide and Pd(OAc) 2. Wide varieties of diethyl phosphates derived from N -arylmandelamides were converted almost quantitatively into oxindoles. When N, N -dibenzylamide was used instead of an anilide substrate, a benzo-fused δ-lactam was obtained. An oxindole product was subjected to substitution reactions to afford 3,3-diaryloxindoles with two different aryl groups.

AN EFFICIENT SYNTHESIS OF α-KETO AMIDES VIA REACTION OF α-(N-METHYLANILINO)-ACETONITRILE WITH ESTERS FOLLOWED BY HYDROLYSIS USING COPPER (II) ACETATE

An efficient sequence proposed for the conversion of esters to α-keto amides involves the reaction of α-(N-methylanilino)-acetonitrile with esters to afford β0hydroxy-α-cyanoenamines of which hydrolysis using copper (II) acetate gives the corresponding α-keto amides in good yields.