868990-46-9Relevant articles and documents
New approaches for the synthesis of isotopically labelled guanidine-derived amino acids and noradrenaline reuptake inhibitors
Bischoff, Roland,Hamilton, Deborah J.,Jobson, Nicola K.,Sutherland, Andrew
, p. 323 - 326 (2008/02/05)
A new approach for the stereoselective synthesis of guanidine-derived amino acids, L-arginine and (+)-blastidic acid, has been devised which allows the selective incorporation of isotopic labels in both the side chain of the amino acid as well as the guanidine unit. A new asymmetric synthesis of the (S,R)-diastereomer of reboxetine, an antidepressant, has also been completed which allows the specific incorporation of radiolabelled iodine for SPECT imaging. Copyright
A highly efficient, asymmetric synthesis of blastidic acid: The β-amino acid component of the antibiotic, (+)-blasticidin S
Bischoff, Roland,McDonald, Niall,Sutherland, Andrew
, p. 7147 - 7149 (2007/10/03)
A new approach for the asymmetric synthesis of blastidic acid, the β-amino acid component of the antibiotic, (+)-blasticidin S has been achieved in 11 steps and 30% overall yield. The key transformations involve a one-pot Swern/Wittig reaction sequence to