869006-55-3

Upstream product

• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 98-80-6 phenylboronic acid 
• 120186-59-6 (4-(benzyloxy)phenyl)magnesium bromide 
• 869006-52-0 4-(4-(benzyloxy)phenyl)-3-bromo-7-methoxy-1,2-dihydronaphthalene 
• 308812-06-8 4-(4-(benzyloxy)phenyl)-7-methoxy-3-phenyl-1,2-dihydronaphthalene 

Relevant academic research and scientific papers

Estrogen receptor ligands. Part 14: Application of novel antagonist side chains to existing platforms

Two novel side chains which had previously been found to enhance antagonist activity in the dihydrobenzoxathiin SERM series were applied to three existing platforms. The novel side chains did not improve the antagonist activity of the existing platforms.

Compounds and process for preparing the same

Cis and trans isomers of 1,2-diphenyl-1,2,3,4-tetrahydronaphthalenes, novel processes for the preparation thereof, and novel intermediates are disclosed herein. The novel 1,2-diphenyl-1,2,3,4-tetrahydronaphthalenes have utility as antifertility estrogenic, anti-estrogenic, anti-spermatogenic, cholesterol lowering and lipid normalizing agents.