869063-82-1

Upstream product

• 185141-83-7 1-[(2R,3R,3aS,9aR)-3-(2,3-Dihydroxy-propyl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidine-2,4-dione 
• 152868-53-6 2'-Deoxy-2'-C-(formylmethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 151384-08-6 2'-deoxy-2'-α-C-(2-propenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 98-88-4 benzoyl chloride 
• 171503-88-1 2'-deoxy-2'-α-C-(2-hydroxyethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxy)uridine 

Downstream Products

• 1067222-29-0 3-Benzoyl-1-{2-[(2R,3R,3aS,9aR)-2-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione 
• 869063-83-2 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-2'-C-(2-(thymin-1-yl)ethyl)uridine 

Relevant academic research and scientific papers

Synthesis of nucleosides with additional nucleobases

The syntheses of two nucleosides with additional nucleobases in the 2′-position are presented. The nucleosides have two- and one-carbon linkers to the additional nucleobase, respectively. The two nucleosides are synthesized from different strategies. The

Stabilisation of nucleic acid secondary structures by oligonucleotides with an additional nucleobase; synthesis and incorporation of 2'-deoxy-2'-C-(2- (thymine-1-yl)ethyl)uridine

A nucleoside with two nucleobases is incorporated into oligonucleotides. The synthetic building block, 2'-deoxy-2'-C-(2-(thymine-1-yl)ethyl)uridine, 2, is prepared from uridine via 5',3'-TIPDS-protected 2'-deoxy-2'-C-allyluridine by an oxidative cleavage