869066-98-8Relevant academic research and scientific papers
An efficient electrophilic N-amination utilizing in situ generated chloramine under phase transfer conditions
Bhattacharya, Apurba,Patel, Nitin C.,Plata, Robert Erik,Peddicord, Michael,Ye, Qingmei,Parlanti, Luca,Palaniswamy, Venkatapuram A.,Grosso, John A.
, p. 5341 - 5343 (2007/10/03)
An efficient, one-pot, phase transfer N-amination technology was developed. The protocol utilizes chloramine, an inexpensive and safe electrophilic aminating agent potentially viable for commercial manufacturing.
New dual inhibitors of EGFR and HER2 protein tyrosine kinases
Fink, Brian E.,Vite, Gregory D.,Mastalerz, Harold,Kadow, John F.,Kim, Soong-Hoon,Leavitt, Kenneth J.,Du, Karen,Crews, Donald,Mitt, Toomas,Wong, Tai W.,Hunt, John T.,Vyas, Dolatrai M.,Tokarski, John S.
, p. 4774 - 4779 (2007/10/03)
A novel series of dual EGFR and HER2 inhibitors based on the pyrrolo[2,1-f][1,2,4]triazine nucleus is described. A general route toward their synthesis, which enables functionalization at multiple sites, has been developed. Biological evaluation in enzyma
