52921-22-9

Usage

Uses

Used in Pharmaceutical Industry:
Diethyl 3-ethyl-1H-pyrrole-2,4-dicarboxylate is used as a starting material for the synthesis of various pharmaceutical compounds. Its biological activities, including antifungal and anticancer properties, make it a valuable building block in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, Diethyl 3-ethyl-1H-pyrrole-2,4-dicarboxylate serves as a starting material for the synthesis of agrochemicals. Its potential applications in this field contribute to the development of new products for agricultural use.
Used in Medicinal Chemistry Research:
Diethyl 3-ethyl-1H-pyrrole-2,4-dicarboxylate is used as a research compound in medicinal chemistry. Its biological activities are of interest to scientists working on the discovery and development of new therapeutic agents.

Upstream product

• 2999-46-4 Ethyl isocyanoacetate 
• 123-38-6 propionaldehyde 
• 93475-39-9 4-ethyl-pyrrole-2,3,5-tricarboxylic acid-3,5-diethyl ester 
• 55314-57-3 ethyl pent-2-ynoate 
• 3750-83-2 4-acetoxy-3-nitrohexane 
• 100141-13-7 3-ethyl-5-bromo-pyrrole-2,4-dicarboxylic acid diethyl ester 

Downstream Products

• 869066-98-8 1-amino-3-ethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester 
• 69687-81-6 ethyl 3-ethyl-1H-pyrrole-2-carboxylate 
• 310443-45-9 4-[[1-(Phenylmethyl)-1H-indazol-5-yl]amino]-5-ethylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester 
• 888709-57-7 [4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-acetonitrile 
• 310444-99-6 5-Ethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid 
• 310443-74-4 [4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-methanol 
• 888709-52-2 4-(1-benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde 

Relevant academic research and scientific papers

Pyrrolotriazine inhibitors of kinases

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Remarkable solvent effect in Barton-Zard pyrrole synthesis: application in an efficient one-step synthesis of pyrrole derivatives

A unique solvent effect encountered in the Barton-Zard pyrrole synthesis was exploited to develop an efficient synthesis of pyrrole-2-esters. The chemistry was extended to a one-pot synthesis of pyrrole-2,4-dicarboxylates.

New dual inhibitors of EGFR and HER2 protein tyrosine kinases

A novel series of dual EGFR and HER2 inhibitors based on the pyrrolo[2,1-f][1,2,4]triazine nucleus is described. A general route toward their synthesis, which enables functionalization at multiple sites, has been developed. Biological evaluation in enzyma

Nonionic superbase-promoted synthesis of oxazoles and pyrroles: Facile synthesis of porphyrins and α-C-acyl amino acid esters

The reaction of acyl chlorides or acid anhydrides with isocyanoacetates in the presence of the superior strong nonionic base P(MeNCH2CH2)3N (1) gave oxazoles in 98-99% yield. Treatment of the oxazoles with HCl-MeOH gave α-